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Compared to testosterone and other anabolic steroids and pro hormones, the advantage of SARMs such as (Ostarine) MK-2688 is that they do not have androgenic activity in non-skeletal-muscle tissuesand therefore do not have the potential to induce anabolic effects in the muscles. In addition, the potential for SARMs and similar synthetic anabolic steroids to cause skeletal muscle hypertrophy and atrophy is lower (Table 2). Table 2. SARMs and similar synthetic anabolic steroids can also cause skeletal muscle hypertrophy and atrophy. Source of SARM(s) or similar synthetic anabolic steroids that cause muscle hypertrophy and atrophy?Discussion SARMs and similar synthetic anabolic steroids may cause skeletal muscle hypertrophy and atrophy if they are used for a wide range of reasons, including the treatment of male pattern hair loss (6), weight loss among male athletes (6), and weight loss among female athletes . In the first report to suggest that SARMs may cause skeletal muscle hypertrophy and atrophy , we found the muscle biopsy samples from young female athletes at the end of the second (postnatal) time point to be significantly more hypertrophyed than those from older female athletes, whose biopsies were taken throughout puberty. In this group, muscle biopsies from a younger group (postpubescence) were also found to be significantly more hypertrophyed than those of younger (pubescence) female athletes. This finding suggests that the skeletal muscle of the older women in the postpubescence group was more than twice as hypertrophyed as that of the younger women. Other authors that have examined the effects of SARMs among male athletes have suggested that even in otherwise healthy, young, physically active men with no known history of muscle atrophy[8,9], bone mineral has been compromised (10,11). However, many reports suggest that a lower bone mass is not a direct cause of hypertrophy or hyperplasia of the muscle, but rather is an indicator of a greater likelihood of further muscle growth and maintenance at these lower levels of skeletal muscle mass compared to those who are hypertrophy-resistant [6,12]. In a study in which 20-s cycle muscle biopsy samples from young men and young women were examined to check for muscle damage and inflammation, we found that the samples from youth women, but not youth men, had significantly higher concentrations of muscle damage markers, including C-reactive protein, interleukin 6 (IL-6), tumor necrosis factor alpha (TNF alpha), and fibrinogen, in the muscle biopsies of the younger women, compared to those from the olderRelated Article: